Been watching T.U.F.F. Puppy recently, and The Chameleon strikes me as very familiar.

Above via Share TV.
So let’s see…
Pathetically skinny, puny frame.
Exaggerated foreign accent.
Tendency towards insane, spittle-launching laughter where his eyes bug out and his teeth go all gappy.
Why, hello there Ren.

Above via The Angry Medic.
They even have similar head and face shape.
It gets even better when The Chameleon disguises himself as a dog:

Since Ren is an ‘asthma hound’.

Above via Tower Video.
See also similar themed posts:
Alien Races of Warhammer 40,000 and Mass Effect
Star Wars’ General Grievous = Warhammer 40,000′s Necron Lord
Enchanted’s Queen Narissa = Final Fantasy 8’s Sorceress Edea
Silly Coincidences Between One Piece and Hunter x Hunter
Tags: Ren and Stimpy, T.U.F.F. Puppy, TUFF Puppy